Translational Value of Proton MRS in Depression: Applications to Preclinical Models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00140654" target="_blank" >RIV/00216224:14110/25:00140654 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/referenceworkentry/10.1007/978-3-031-32035-4_39-1" target="_blank" >https://link.springer.com/referenceworkentry/10.1007/978-3-031-32035-4_39-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-32035-4_39-1" target="_blank" >10.1007/978-3-031-32035-4_39-1</a>

Result language
angličtina
Original language name
Translational Value of Proton MRS in Depression: Applications to Preclinical Models
Original language description
This chapter compares the consistent 1H MRS evidence from the animal models to the clinical findings. The clinical results largely correspond to the animal studies in the prefrontal cortex, where the higher choline and lower glutamax (glutamate+glutamine) levels are reported. This marker indicates cell membrane turnover and neuronal metabolism dysfunction. The hippocampus in MDD patients is understudied in the clinical field making an assessment of consistency of preclinical and clinical findings impossible. Use of 1H MRS method provides new insights into neuro-molecular process in MDD and has a potential to become a useful biomarker for tracking the success of treatment interventions in MDD.
Czech name
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Czech description
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Project
<a href="/en/project/LM2023050" target="_blank" >LM2023050: National Infrastructure for Biological and Medical Imaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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