Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F23%3A00573416" target="_blank" >RIV/68081731:_____/23:00573416 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00130976
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0278584623000945" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0278584623000945</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pnpbp.2023.110808" target="_blank" >10.1016/j.pnpbp.2023.110808</a>
Alternative languages
Result language
angličtina
Original language name
Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression
Original language description
Major depressive disorder (MDD) is underlined by neurochemical changes in the brain. Proton magnetic resonance spectroscopy (1H MRS) is a useful tool for their examination as it provides information about the levels of metabolites. This review summarises the current knowledge of 1H MRS findings from rodent models of MDD, assesses the results from both a biological and a technical perspective, and identifies the main sources of bias. From a technical point of view, bias-introducing factors are the diversity of the measured volumes and their positioning in the brain, the data processing, and the metabolite concentration expression. The biological variables are strain, sex, and species, as well as the model itself, and in vivo vs. ex vivo exploration. This review identified some consistency in the 1H MRS findings in the models of MDD: lower levels of glutamine, glutamate + glutamine, and higher levels of myo-inositol and taurine in most of the brain regions of MDD models. This may suggest changes in regional metabolism, neuronal dysregulation, inflammation, and a compensatory effect reaction in the MDD rodent models.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Progress in Neuro-Psychopharmacology & Biological Psychiatry
ISSN
0278-5846
e-ISSN
1878-4216
Volume of the periodical
127
Issue of the periodical within the volume
20 December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
110808
UT code for WoS article
001058514600001
EID of the result in the Scopus database
2-s2.0-85162866247