Translational Value of Proton MRS in Depression: Applications to Preclinical Models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00647862" target="_blank" >RIV/68081731:_____/25:00647862 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/rwe/10.1007/978-3-031-73368-0_39" target="_blank" >https://link.springer.com/rwe/10.1007/978-3-031-73368-0_39</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-73368-0_39" target="_blank" >10.1007/978-3-031-73368-0_39</a>
Alternative languages
Result language
angličtina
Original language name
Translational Value of Proton MRS in Depression: Applications to Preclinical Models
Original language description
Major depressive disorder (MDD) is a chronic mental disease affecting over 300 million people worldwide with limited treatment options. Understanding the neurochemical processes in MDD is essential for developing innovative medications, and magnetic resonance spectroscopy ([[sup]]1[[/sup]]H MRS) is especially well-suited for its in vivo exploration. This chapter compares the consistent [[sup]]1[[/sup]]H MRS evidence from the animal models to the clinical findings. The clinical results largely correspond to the animal studies in the prefrontal cortex, where the higher choline and lower Glx (glutamate + glutamine) levels are reported. These markers indicate cell membrane turnover and neuronal metabolism dysfunction. The hippocampus in MDD patients is understudied in the clinical field making an assessment of consistency of preclinical and clinical findings impossible. The use of [[sup]]1[[/sup]]H MRS method provides new insights into neuro-molecular process in MDD and has a potential to become a useful biomarker for tracking the success of treatment interventions in MDD.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Handbook of the Biology and Pathology of Mental Disorders
ISBN
978-3-031-73367-3
Number of pages of the result
22
Pages from-to
941-962
Number of pages of the book
3457
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
—