Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00119770" target="_blank" >RIV/00216224:14160/21:00119770 - isvavai.cz</a>
Result on the web
<a href="https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-6-12/preformulacni-design-plga-casticoveho-systemu-pro-vicedenni-uvolnovani-antidepresiva-mirtazapinu-129704/download?hl=cs" target="_blank" >https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-6-12/preformulacni-design-plga-casticoveho-systemu-pro-vicedenni-uvolnovani-antidepresiva-mirtazapinu-129704/download?hl=cs</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine
Original language description
In this experimental study, the biodegradable polylactide-co-glycolide (PLGA) microparticles (MP) loaded with the insoluble antidepressant mirtazapine were prepared by the simple o/w solvent evaporation method. The formation involved intrinsic variables, such as the content of polymer (700, 900 or 1200 mg), dichloromethane (5 or 10 ml) and/or drug (200 or 400 or 600 mg), and the volume of the aqueous emulsion phase (400, 600 or 800 ml). The influence of these parameters on the size and morphology of microparticles, encapsulation efficiency, and drug release behavior was observed. All MP were successfully prepared, and their size ranged between 165.34 ± 42.88 and 360.17 ± 121.59 μm. MP exhibited prolonged drug release (days), and some profiles had multiphasic character. It was found that the samples prepared with a higher initial amount of PLGA were bigger with prolonged lag time up to 34.3 hours. On the other hand, higher drug concentrations reduced the lag time. The external phase volume reduction and multiplication of dichloromethane amount prolonged the mirtazapine release and decreased the encapsulation efficiency. These observations were further confirmed by multivariate data analysis.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/QK1810221" target="_blank" >QK1810221: Using of microparticles as carriers of hormonally active substances in artificial reproduction of fish.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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