Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00122004" target="_blank" >RIV/00216224:14160/21:00122004 - isvavai.cz</a>

Result on the web

<a href="https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748" target="_blank" >https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles

Original language description

Microparticles based on biodegradable synthetic lactic acid and glycolic acid copolymer (PLGA) were successfully prepared by the solvent evaporation method. Ibuprofen was chosen as the model drug. Various formulation and process parameters have been used to prepare each sample with emphasis on size reduction. The effect of the emulsification method (direct emulsification or emulsification using an ULTRATURRAX or a NE-1000 dispenser), the volume of the aqueous phase (200, 800 ml) and the stirring speed of the emulsion system (600, 1000 rpm) on the characteristic properties of microparticles, such as encapsulation efficiency, drug loading and particle morphology, was observed. The resulting microparticles were evaluated by optical microscopy or laser diffraction and the dissolution test was performed. It was found that the sample prepared by direct emulsification with 800 ml of an aqueous phase at 600 rpm provided the most favorable results, meanwhile the emulsification prestep using a homogenizer caused promising particle size reduction. Gradual emulsification was evaluated as inapplicable due to great losses.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

32-40

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85111416545