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Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00123238" target="_blank" >RIV/00216224:14160/21:00123238 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates

  • Original language description

    Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů