Investigation of Properties of Selected Carbamates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126517" target="_blank" >RIV/00216224:14160/22:00126517 - isvavai.cz</a>
Result on the web
<a href="https://fns.uniba.sk/fileadmin/prif/svk/zborniky/Zbornik_SVK_2022.pdf" target="_blank" >https://fns.uniba.sk/fileadmin/prif/svk/zborniky/Zbornik_SVK_2022.pdf</a>
DOI - Digital Object Identifier
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Result language
slovinština
Original language name
Hodnotenie vlastností vybraných karbamátov
Original language description
This work deals with the evaluation of lipophilicity and stability of selected carbamates using high performance liquid chromatography. A method using C18 reverse stationary phase and isocratic conditions was used to determine lipophilicity. The methanol:water mobile phase was used to determine the capacity factor k, while the methanol:acetate buffer (pH 6.5 and pH 7.4) was used to determine the distribution coefficient D. Prediction of lipophilicity by in silico methods was performed using three software with different algorithms: ChemBioDraw Ultra, ACD/Percepta and MOLinspiration. The carbamate with the weakest steric protection, i.e. with the expected highest degradability, was chosen for stability monitoring. The developed HPLC method using phenyl stationary phase and acetonitrile:phosphate buffer (pH 2.5) as the mobile phase provided sufficient resolution between the studied carbamate and its degradant, pattern anilide.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Študentská vedecká konferencia PriF UK 2022 Zborník recenzovaných príspevkov
ISBN
9788022353854
ISSN
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e-ISSN
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Number of pages
1189
Pages from-to
766-771
Publisher name
Univerzita Komenského v Bratislave
Place of publication
Bratislava
Event location
Bratislava
Event date
Apr 27, 2022
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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