Cyclooxygenase and Lipoxygenase Inhibitors Potentiate Antiproliferative, Apoptotic and Differentiation effects of TNFa on human leukemic HL-60 cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F00%3A00005237" target="_blank" >RIV/00216224:14310/00:00005237 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cyclooxygenase and Lipoxygenase Inhibitors Potentiate Antiproliferative, Apoptotic and Differentiation effects of TNFa on human leukemic HL-60 cells
Original language description
Our results indicated that indomethacin alone has only minor effects on the measured parameters, however it potentiated (in concentration dependent manner) antiproliferative and apoptotic effects of TNFa, as well as CD11b/14 expression. NSE activity andROI production after TNFa treatment was not influenced by indomethacin. After combined treatment of cells with indomethacin and TNFa an increased percentage of cells in S-phase of the cell cycle was observed. On the other hand, MK-886 alone dose-dependently reduced proliferation and viability of HL-60 cells, induced apoptosis and increased amount of cells in G1 phase of the cell cycle. These effects were further potentiated by combination with TNFa. Moreover, when combined with TNFa MK-886 significantlyincreased NSE activity, ROI production and CD11b/14 expression, i. e. it potentiated differentiation of HL-60 cells. In conclusion, while inhibition of cyclooxygenase potentiates the antiproliferative and the apoptotic effects of TNFa, i
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA524%2F99%2F0694" target="_blank" >GA524/99/0694: Polyunsaturated fatty acids and cytokines - their role in maintenance of homeostasis at the cell population level</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
11th European Students' Conference at the Charité Berlin
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
141
Publisher name
Charité
Place of publication
Berlín, SRN
Event location
Berlín
Event date
Jan 1, 2000
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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