Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F01%3A00005223" target="_blank" >RIV/00216224:14310/01:00005223 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha
Original language description
Tumor necrosis factor-a (TNF) is a pleiotropic cytokine. Besides other effects it promotes differentiation of leukaemic cells and activates (phosphorylates) jun-NH2-terminal kinase (JNK). JNK activation might be involved in signalling pathway leading todifferentiation. MK-886 alone did not cause differentiation, however it increased non-specific esterase activity, reactive oxygen intermediates production and CD11b/CD14 cell surface antigen expression after TNF treatment, i. e. it potentiated differentiation of HL-60 cells. On the other hand indomethacin alone or in combination with TNF did not influence measured parameters of differentiation. Neither indomethacin, nor MK-886 influenced JNK activation. We concluded that endogenous LOX metabolites mightplay negative role in differentiation induced by TNF and that this effect is independent of JNK activation. These results may be beneficial for leukaemic patients.
Czech name
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Czech description
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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