Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F99%3A00001303" target="_blank" >RIV/00216224:14310/99:00001303 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration
Original language description
TPA is known activator of protein kinase C. This activation subsequently reduces proliferation and induces differentiation and apoptosis of human myeloid leukaemia cell line HL-60. We have studied possible role of arachidonic acid metabolites in these processes. The reduction of proliferation and the induction of differentiation were not influenced either by indomethacin or MK-886. While indomethacin did not affect the percentage of apoptotic cells, MK-886 combined with TPA significantly enhanced the amount of apoptotic cells in concentration in which MK-886 alone did not induce apoptosis. Assuming that the enhancement of apoptosis by MK-886 was caused by 5-LPO inhibition, blocking the 5-LPO activity could contribute to leukaemia treatment.
Czech name
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Czech description
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Project
<a href="/en/project/GA524%2F99%2F0694" target="_blank" >GA524/99/0694: Polyunsaturated fatty acids and cytokines - their role in maintenance of homeostasis at the cell population level</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
1999
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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