New model for evaluation of endocrine disruption of steroidogenesis in H295R cell line

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014599" target="_blank" >RIV/00216224:14310/05:00014599 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New model for evaluation of endocrine disruption of steroidogenesis in H295R cell line

Original language description

One of the most hazardous properties of xenobiotics is their ability to interact with endocrine system of the organisms leading to number of negative consequences. After discovery of endocrine disrupting potential of wide range of environmental pollutants, the main concern was devoted to study of mechanism of interaction between xenobiotic compounds and steroid hormone receptors (particularly interaction with estrogenic receptor). Less attention was focused on other parts of this signaling pathway, suchas steroidogenesis, which is involved in steroid signaling pathway that regulates many crucial physiologic processes such as carcinogenesis, immunotoxicity or reduced fecundity. We have developed a model for assessment of the potency of various chemicals or their mixtures (pharmaceuticals, environmental contaminants, pesticides...) to affect levels of produced steroids. The model is based on a human carcinoma cell line H295R, which retains the ability to synthesize most of the important

Czech name

Nový model pro hodnocení endokrinní disrupce steroidogeneze v buněčné linii H295R

Czech description

One of the most hazardous properties of xenobiotics is their ability to interact with endocrine system of the organisms leading to number of negative consequences. After discovery of endocrine disrupting potential of wide range of environmental pollutants, the main concern was devoted to study of mechanism of interaction between xenobiotic compounds and steroid hormone receptors (particularly interaction with estrogenic receptor). Less attention was focused on other parts of this signaling pathway, suchas steroidogenesis, which is involved in steroid signaling pathway that regulates many crucial physiologic processes such as carcinogenesis, immunotoxicity or reduced fecundity. We have developed a model for assessment of the potency of various chemicals or their mixtures (pharmaceuticals, environmental contaminants, pesticides...) to affect levels of produced steroids. The model is based on a human carcinoma cell line H295R, which retains the ability to synthesize most of the important

Type

D - Article in proceedings

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

ECOTOX 2005

ISBN

8021037997

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

29

Publisher name

Brno : Masaryk University, 2005.

Place of publication

Brno

Event location

Brno

Event date

Sep 5, 2005

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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