Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00021389" target="_blank" >RIV/00216224:14310/05:00021389 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Thermodynamic and structures of Pseudomonas aeruginosa lectins and their interaction with complex human glycoconjugates

Original language description

Carbohydrate-mediated recognition plays an important role in the ability of pathogenic bacteria to adhere to the surface of the host cell in the first step of their invasion and infectivity. Together with carbohydrate receptors located on pili and flagellum, Pseudomonas aeruginosa also expresses soluble galactose- and fucose-binding lectins (PA-IL and PA-IIL). Complexes between both lectins and their monosaccharide ligands have been characterized by a variety of methods, including enzyme-amplification (ELLA), titration microcalorimetry, x-ray crystallography and molecular modeling. PA-IIL displays an affinity for fucose in micromolar range, unusually high for monosaccharide binding. These characteristics are correlated to the remarkable presence of twocalcium ions in the binding site of the protein. When searching for ligands of biological interest, PA-IIL lectin displays highest affinity for lewis a, a trisaccharide located on epithelial cell glycoconjugates of CF patients, and human

Czech name

Termodynamika a struktura lektinu Pseudomonas aeruginosa a jejich interakce s lidskými glykokonjugáty

Czech description

Termodynamika a struktura lektinu Pseudomonas aeruginosa a jejich interakce s lidskými glykokonjugáty

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Glycoconjugate Journal

ISSN

0282-0080

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

4/5/6

Country of publishing house

US - UNITED STATES

Number of pages

1

Pages from-to

278-278

UT code for WoS article

—

EID of the result in the Scopus database

—