Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00025289" target="_blank" >RIV/00216224:14310/08:00025289 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids.

Original language description

Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Retinoids are dietary hormones acting through nuclear receptors for retinoic acid, important especially during embryonic development. This study focuses on the disruptionof signaling pathways of retinoids by polycyclic aromatic hydrocarbons (PAHs) and their N-heterocyclic analogs (N-PAHs), important environmental contaminants with numerous biological effects. In vitro test with P19/A15 cell line stably transfected with luciferase reporter gene under control of retinoic acid responsive elements was used to investigate both direct activation of retinoic acid receptors and modulation of response induced by natural ligand all-trans-retinoic acid (ATRA) by 26 PAHs and N-PAHs. While none of individual compounds alone activated retinoic acid receptors, many of them modulated ATRA-mediated activity both after 6 h and 24 h exposure. Majority of compounds active after 6 h downregulated ATRA - mediated activity (m

Czech name

Narušení signálování retinoidů polycyklickými aromatickými uhlovodíky a jejich N-heterocyclickými analogy

Czech description

Narušení signálování retinoidů polycyklickými aromatickými uhlovodíky a jejich N-heterocyclickými analogy ve studii in vitro.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology in vitro

ISSN

0887-2333

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

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UT code for WoS article

000261583800014

EID of the result in the Scopus database

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