The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00053414" target="_blank" >RIV/00216224:14310/11:00053414 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.toxlet.2010.11.011" target="_blank" >http://dx.doi.org/10.1016/j.toxlet.2010.11.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.toxlet.2010.11.011" target="_blank" >10.1016/j.toxlet.2010.11.011</a>

Result language
angličtina
Original language name
The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.
Original language description
This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may haveinfluence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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