INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00016464" target="_blank" >RIV/00216224:14310/06:00016464 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
INTERFERENCE OF PAHs AND THEIR DERIVATIVES WITH SIGNALING OF RETINOIDS
Original language description
For studying the disruption, we used new in vitro method with the cell line P19/A15. It is murine embryonal P19 cell line stably transfected with luciferase reporter gene under the control of RARE (Retinoic Acid Responsive Element). Xenobiotics potentially interacting with the retinoid signaling can either induce luciferase expression and/or negatively affect retinoic acid (ATRA)-induced luciferase activity. For our study we selected the group of PAH and their N-heterocyclic analogs especially for theirwidespread environmental occurrence and possible teratogenic effects. We tested 13 N-PAHs and 6 PAHs for retinoid and antiretinoid activity.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů