INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00020852" target="_blank" >RIV/00216224:14310/07:00020852 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING
Original language description
Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis. Some effects, such as malformations in frogs or changes in metabolism of birds, could be related to disruption of the retinoid signaling pathwayby exposure to organic contaminants. A new reporter gene assay has been established for evaluation of the modulation of retinoid signaling by individual chemicals or environmental samples. The bioassay is based on the pluripotent embryonic carcinoma cellline P19 stably transfected with the firefly luciferase gene under the control of a retinoic acid responsive element (clone P19/ A15). The cell line was used to characterize the effects of individual chemicals and sediments extracts on retinoid signaling pathways. The extracts of sediments from the River Kymi, Finland, which contained polychlorinated dioxins and furans and polycyclic aromatic hydrocarbons (PAHs), significantly increased the potency of all trans retinoic acid (ATRA), whi
Czech name
Interference extraktů kontaminaovaných sedimentů a environmentálních polutantů se signálováním retinoidů
Czech description
Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis. Some effects, such as malformations in frogs or changes in metabolism of birds, could be related to disruption of the retinoid signaling pathwayby exposure to organic contaminants. A new reporter gene assay has been established for evaluation of the modulation of retinoid signaling by individual chemicals or environmental samples. The bioassay is based on the pluripotent embryonic carcinoma cellline P19 stably transfected with the firefly luciferase gene under the control of a retinoic acid responsive element (clone P19/A15). The cell line was used to characterize the effects of individual chemicals and sediments extracts on retinoid signalingpathways. The extracts of sediments from the River Kymi, Finland, which contained polychlorinated dioxins and furans and polycyclic aromatic hydrocarbons (PAHs), significantly increased the potency of all trans retinoic acid (ATRA), whil
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Chemistry
ISSN
1552-8618
e-ISSN
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Volume of the periodical
26/2007
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1591-1599
UT code for WoS article
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EID of the result in the Scopus database
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