Disruption of retinoid signalling by 2,3,7,8-TCDD and phthalates on P19/A15 cell line
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014611" target="_blank" >RIV/00216224:14310/05:00014611 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Disruption of retinoid signalling by 2,3,7,8-TCDD and phthalates on P19/A15 cell line
Original language description
Natural retinoids - vitamin A and its metabolites - are very important signalling molecules in eukaryotic organisms. They are necessary for vision, play an important role in cell growth, differenciation and apoptosis, influence embryonic development andfunction of nervous and immunity system, etc. In our study, we used an embryonic cell line P19/A15 stably transfected with luciferase gene under control of retinoic acid receptor (RAR) for investigation of effects of eight different phtalates and 2,3,7,8tetrachlorodibenzodioxin (TCDD) on retinoid signalling. Disruption of retinoid homeostasis as a result of exposure to dioxin-like substances has been described elsewhere. Furthermore, some studies suggested also direct downregulation of retinoid-dependent effects by TCDD. Phthalates widespread polutants released particularly from chemical industry have a similar structure to retinoids and for that reason we decided to investigate their possible interaction with retinoid pathway. P19/A15
Czech name
Disrupce signálování retinoidů 2,3,7,8-TCDD a ftaláty v buněčné linii P19/A15
Czech description
viz angl.
Classification
Type
D - Article in proceedings
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Joint Conference of Scandinavian Society of Cell Toxicology and Estonian Society of Toxicology
ISBN
9949-13-297-5
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
61-61
Publisher name
SSCT-EST
Place of publication
Tallinn
Event location
Toila, Estonsko
Event date
Oct 20, 2005
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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