Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00039163" target="_blank" >RIV/00216224:14310/09:00039163 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.
Original language description
In the present study, we have attempted to build model of the GnT-V 3D-structure. We obtain altogether 10 models of the GnT-V structure. On the basis of the 3D-structure analysis we have chosen five models for the molecular dynamic equilibration in water. All structure models have been equilibrated at 300 K during 4ns. The molecular dynamic simulation show, that more reliable model might be the model based on the MurG template. Due to these result we did multiple sequence alignment with another seven members of this family, including MurG, to observe more precise alignment. In addition we also took one glycosyltransferase, which family has not been specified yet, a-1,6-fucosyltransferase FUT8 (2DE0).
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů