c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040620" target="_blank" >RIV/00216224:14310/10:00040620 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D
Original language description
c-Myb is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types including breast and colon cancer. Its role in control of invasion and metastasis of tumor cells remains unclear. This study shows that overexpession of c-Myb enhances ability of human breast cancer MDA-MB-231 cells and mouse colon cancer CT26 cells to migrate and invade Matrigel in vitro. Real-time analysis of cell migrationand invasion using the xCELLigence RTCA system revealed dynamics of c-Myb-induced effects with rapid onset of migration and invasion during first 6 and 12 hours, respectively. Real-time PCR screening revealed up-regulation of cathepsin D and matrix metalloproteinase 9 (MMP9) mRNAs coding for proteases that promote invasive behavior in c-Myb-overexpressing cells. Further experiments confirmed that increased production of cathepsin D and MMP 9 correlate with c-Myb-induced invasivity of MDA
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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