Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044389" target="_blank" >RIV/00216224:14310/10:00044389 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator

Original language description

The purpose of this study was to explore effect of TBT on expression of genes involved in estrogenic responses, fat and glucose metabolism and metabolic pathways common for xenobiotics and TBT interaction with cAMP signaling towards these genes. Atlanticsalmon (salmo salar) was exposed to three concentrations of TBT and consequently to forskolin (an adenylyl cyclase activator). The mRNA expression and protein levels of estrogenic receptor, peroxisome proliferator-activated receptors, ACOX-1, pregnane Xreceptor, CYP3A and GST in salmon liver were determined using QRT-PCR and western-blotting.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Aquatic toxicology

ISSN

0166-445X

e-ISSN

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Volume of the periodical

99

Issue of the periodical within the volume

2

Country of publishing house

NO - NORWAY

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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