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Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of biological microsamples

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044535" target="_blank" >RIV/00216224:14310/10:00044535 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of biological microsamples

  • Original language description

    A new method for determination of trace elements in submicroliter sample volumes using substrate-assisted laser desorption inductively-coupled plasma mass spectrometry (SALD ICP MS ) is presented. In contrast to conventional laser ablation (LA) ICP MS, SALD ICP MS allows quantitative analysis of metals in liquid samples because of complete sample desorption, which can be achieved using a few pulses with spot-to-spot reproducibility below 6 %. Detailed characterization, such as laser power density, raster and point desorption optimization etc. will be discussed. The performance of off-line coupling capillary electrophoresis and SALD ICP was demonstrated on speciation of 1 pg of Cr(III) and Cr (VI). SALD ICP MS can be used for the determination of traceelements in minute amounts of biological samples at physiological level as demonstrated on the determination of copper in myeloid leukemia cells to investigate the role of copper ions in cytotoxicity regulation with disulfiram .

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA203%2F09%2F1025" target="_blank" >GA203/09/1025: Multidetection platform for microcolumn separation of proteins and peptides</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Sborník 14. česko ? slovenské spektroskopické konference

  • ISBN

    978-80-7395-282-2

  • ISSN

  • e-ISSN

  • Number of pages

    149

  • Pages from-to

  • Publisher name

    Spektroskopická společnost Jana Marka Marci

  • Place of publication

    Pardubice

  • Event location

    Litomyšl

  • Event date

    Jan 1, 2010

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article