Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049905" target="_blank" >RIV/00216224:14310/11:00049905 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12223-011-0007-3" target="_blank" >http://dx.doi.org/10.1007/s12223-011-0007-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-011-0007-3" target="_blank" >10.1007/s12223-011-0007-3</a>

Result language

angličtina

Original language name

Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators

Original language description

In the facultatively anaerobic bacterium Paracoccus denitrificans, the synthesis of many proteins involved in energy metabolism is regulated by the FNR-type transcription factors (FnrP, NNR and NarR). One of them, NarR, senses nitrate or nitrite concentration and promotes expression of the membrane-bound nitrate reductase genes. It can also be activated by azide as a non-metabolizable analogue of nitrate. In this work we show that one of the most prominent protein species inducible by azide is a Fe/Mn-family superoxide dismutase (SOD). Azide induces SOD at protein, mRNA transcript and enzyme activity levels in the aerobically growing cells. Since SOD expression remains unaffected in the fnrP, nnr and narR mutant strains, we postulate a mechanism independent of the known FNR-type regulators but involving a redox signal arising from the respiratory chain.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Microbiologica

ISSN

0015-5632

e-ISSN

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Volume of the periodical

56

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

13-17

UT code for WoS article

000290451500003

EID of the result in the Scopus database

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