All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

A solution study of protonation chemical equlibria of nucleobases and short oligonucleotides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00053670" target="_blank" >RIV/00216224:14310/11:00053670 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    A solution study of protonation chemical equlibria of nucleobases and short oligonucleotides

  • Original language description

    The protonation constants of nucleobases and relevant nucleosides and nucleotides were determined by means of potenciometry and molecular absorption spectroscopy in UV region (I=0.15 mol.l-1 NaCl,t=25C) and the experimental data were evaluated by OPIUM program. In addition, thermodynamic parameters for nucleobase ligands were estimated. Also, some examples of ligand complexation by transition metal ions (e.g. copper(II),zinc(II),kadmium(II)) will be presented and their importance for bioligand speciation will be discussed. The protonation behavior of ODN containing C, i.e.(CCC)n,n=1?3, was followed by means of molecular spectroscopy in pH region 2?8 and variable temperature and ionic strength adjusted by NaCl. The experimental data were treated by means of OPIUM, MCR ? ALS and EQUISPEC software and distribution diagram of species as pH fuction were calculated. For comparison, the protonation behavior of ODN with the (CAC)3, A3C3C3 and C3A3C3 sequence was also investigated.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů