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Structural insight into binding variability of Aspergillus fumigatus lectin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057542" target="_blank" >RIV/00216224:14310/12:00057542 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural insight into binding variability of Aspergillus fumigatus lectin

  • Original language description

    We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA303%2F09%2F1168" target="_blank" >GA303/09/1168: Lectins from human pathogens - structure, function, engineering</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů