Structural insight into binding variability of Aspergillus fumigatus lectin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057542" target="_blank" >RIV/00216224:14310/12:00057542 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Structural insight into binding variability of Aspergillus fumigatus lectin
Original language description
We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F09%2F1168" target="_blank" >GA303/09/1168: Lectins from human pathogens - structure, function, engineering</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů