SUMO Wrestles with Recombination

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057622" target="_blank" >RIV/00216224:14310/12:00057622 - isvavai.cz</a>

Result on the web

<a href="http://www.mdpi.com/2218-273X/2/3/350" target="_blank" >http://www.mdpi.com/2218-273X/2/3/350</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biom2030350" target="_blank" >10.3390/biom2030350</a>

Result language

angličtina

Original language name

SUMO Wrestles with Recombination

Original language description

DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. Onthe other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins involved in different steps of HR have been shown to undergo modification by small ubiquitin-like modifier (SUMO)peptide and it has been suggested that deficient sumoylation impairs the progression of HR. This review addresses specific effects of sumoylation on the properties of various HR proteins and describes its importance for the homeostasis of DNA repetitivesequences. The article further illustrates the role of sumoylation in meiotic recombination and the interplay between SUMO and other post-translational modifications.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomolecules

ISSN

2218-273X

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

26

Pages from-to

350-375

UT code for WoS article

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EID of the result in the Scopus database

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