Synergistic effects of copper(II) complexes and cisplatin: an application of artificial neural networks and experimental design
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00059906" target="_blank" >RIV/00216224:14310/12:00059906 - isvavai.cz</a>
Result on the web
<a href="http://ismec2012.ist.utl.pt/index.html" target="_blank" >http://ismec2012.ist.utl.pt/index.html</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synergistic effects of copper(II) complexes and cisplatin: an application of artificial neural networks and experimental design
Original language description
Cisplatin is highly effective in treating a variety of cancers [ 1] but both inherited and acquired tumoral cell resistance seriously limits its applications [2]. Anticancer drugs are widely used in suitable combinations in order to improve their action[3]. In the cell, associations of two or more drugs may exhibit synergistic, antagonistic or addictive effects. Synergistic, antagonistic or additive type of interaction occurs when the cytotoxicity of the drug combination is respectively greater, lower,or equal to the sum of the cytotoxicity of individual drugs. Complexes of copper(II) with 1,10-ortho-phenanthroline (phen) are also endowed with cytotoxic and antitumoral effects being capable of cleaving DNA and improving nuclease activity [4].
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů