New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00066011" target="_blank" >RIV/00216224:14310/13:00066011 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2013.01.004" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2013.01.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2013.01.004" target="_blank" >10.1016/j.bmc.2013.01.004</a>

Result language
angličtina
Original language name
New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
Original language description
Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.
Czech name
—
Czech description
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Project
<a href="/en/project/GA203%2F09%2F1345" target="_blank" >GA203/09/1345: Allenyl synthon in synthesis of heterocyclic compounds</a>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP) S - Specificky vyzkum na vysokych skolach I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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