Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00073314" target="_blank" >RIV/00216224:14310/14:00073314 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses
Original language description
The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and innovative antimicrobial strategies. Polyvalent bacteriophages from the family Myoviridae, sub-family Spounavirinae of genus Twort-likephages that infect S. aureus have potential for use in phage therapy. In this study we characterized genomic sequences of the polyvalent staphylococcal phage 812 and its spontaneous host-range mutants selected on non-susceptible S. aureus strains. The wild type phage was shown to lyse up to 65%, whereas host-range mutants up to 95% of S. aureus strains under study. Genomic DNAs of five phages were sequenced using 454 Genome Sequencer Junior (Roche). Bacteriophage DNA sequences were assembled by software GS De novo Assembler and GS Reference Mapper (Roche). Genome of phage K was chosen as the reference.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Russian Journal of Infection and Immunity
ISSN
2220-7619
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
S1
Country of publishing house
RU - RUSSIAN FEDERATION
Number of pages
2
Pages from-to
49-50
UT code for WoS article
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EID of the result in the Scopus database
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