Recombinant antibodies for in vivo applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00073670" target="_blank" >RIV/00216224:14310/14:00073670 - isvavai.cz</a>
Result on the web
<a href="http://www.structbio.org/index.php/conferences/25-xiidiscussions" target="_blank" >http://www.structbio.org/index.php/conferences/25-xiidiscussions</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Recombinant antibodies for in vivo applications
Original language description
Interactions between biomolecules constitute the core of biological functions. In protein?protein interactions, specificity plays a key role and many proteins have evolved into extraordinarily precise molecular machines. The multistep phosphorylation pathway of the cytokinin signaling in plants is involving promiscuous protein-protein interactions, allowing the plasticity of the plant cell response to environmental and developmental stimuli. We have developed a recombinant antibody which is able to precisely bind to a specific protein from the phosporylation pathway in vivo. Hereinafter this protein is not phosphorylated after the signal perception and therefore the message is not delivered to the nucleus to commit the reaction of the plant. To accomplish a successful selection of the recombinant antibody, we have developed a in vivo selection method. This method allows targeting of recombinant antibodies for a precise activity. Along the way of developing our method, we came to severa
Czech name
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Czech description
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Project
<a href="/en/project/GA521%2F09%2F1699" target="_blank" >GA521/09/1699: Immunomodulation as a functional proteomics tool for cytokinin signaling study in Arabidopsis thaliana</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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