Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074205" target="_blank" >RIV/00216224:14310/14:00074205 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method
Original language description
Enantioselective discrimination is an important phenomenon influencing pharmacokinetics and pharmacodynamics of chiral drugs in humans and animals. Metabolism appraisal of single enantiomers of every drug candidate compound thus constitutes the inseparable part of LADME/tox screening. Capillary electrophoresis represents a promising technique in the field of in vitro enzyme assays due to miniscule sample consumption, simple implementation of chiral separations and high-throughput by automation. An optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 3A4 enzyme (CYP3A4) is introduced.
Czech name
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Czech description
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Project
<a href="/en/project/GAP206%2F10%2F0057" target="_blank" >GAP206/10/0057: Miniaturised on-line drug-metabolism system based on capillary electrophoresis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014
ISBN
9788090495920
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
231-232
Publisher name
Institute of Analytical Chemistry AS CR, v. v. i., Brno, Česká republika,
Place of publication
Brno
Event location
Brno
Event date
Oct 20, 2014
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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