Optimized On-Line Enantioselective Capillary Electrophoretic Method for Kinetic and Inhibition Studies of Drug Metabolism Mediated by Cytochrome P450 Enzymes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080623" target="_blank" >RIV/00216224:14310/15:00080623 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/elps.201400356" target="_blank" >http://dx.doi.org/10.1002/elps.201400356</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elps.201400356" target="_blank" >10.1002/elps.201400356</a>
Alternative languages
Result language
angličtina
Original language name
Optimized On-Line Enantioselective Capillary Electrophoretic Method for Kinetic and Inhibition Studies of Drug Metabolism Mediated by Cytochrome P450 Enzymes
Original language description
Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of candidate compounds have to be assessed prior to clinicaltesting. Since biotransformation significantly influences drug actions in an organism, metabolism studies represent a crucial part of such tests. Hence, an optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 enzymes was developed. It comprises a diffusion-based procedure, which enables mixing of the enzyme with virtually any compound inside the nanoliter-scale capillary reactor and without the need of additional optimization of mixing conditions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electrophoresis
ISSN
0173-0835
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
11-12
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1349-1357
UT code for WoS article
000356004200015
EID of the result in the Scopus database
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