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Optimized On-Line Enantioselective Capillary Electrophoretic Method for Kinetic and Inhibition Studies of Drug Metabolism Mediated by Cytochrome P450 Enzymes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080623" target="_blank" >RIV/00216224:14310/15:00080623 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/elps.201400356" target="_blank" >http://dx.doi.org/10.1002/elps.201400356</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/elps.201400356" target="_blank" >10.1002/elps.201400356</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Optimized On-Line Enantioselective Capillary Electrophoretic Method for Kinetic and Inhibition Studies of Drug Metabolism Mediated by Cytochrome P450 Enzymes

  • Original language description

    Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of candidate compounds have to be assessed prior to clinicaltesting. Since biotransformation significantly influences drug actions in an organism, metabolism studies represent a crucial part of such tests. Hence, an optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 enzymes was developed. It comprises a diffusion-based procedure, which enables mixing of the enzyme with virtually any compound inside the nanoliter-scale capillary reactor and without the need of additional optimization of mixing conditions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Electrophoresis

  • ISSN

    0173-0835

  • e-ISSN

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    11-12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    1349-1357

  • UT code for WoS article

    000356004200015

  • EID of the result in the Scopus database