Diabetes, hypertension and stroke - does Alzheimer protect you?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00080179" target="_blank" >RIV/00216224:14310/14:00080179 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/14:A1501DQN RIV/67985904:_____/14:00443234

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Diabetes, hypertension and stroke - does Alzheimer protect you?

Original language description

OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of Alzheimer's disease; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conductingan association study on 373 patients with Alzheimer's disease and 286 unrelated control individuals. The occurrence and the age of onset of diabetes and cardiovascular diseases were evaluated in both groups. Apolipoprotein E genotype was analyzed in allsubjects by PCR method. RESULTS: We report that, in Czech population carrying ApoE4 allele increases risk of Alzheimer's disease 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between ApoE4 allele, Alzheimer's disease and hypertension. Hypertensive subjects with the ApoE4 allele have 1.5-fold greater risk of Alzheimer's disease. Thus, hypertension together with ApoE4 allele translates into 1.5-fold higher risk of AD.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT11152" target="_blank" >NT11152: Epidemiology and genetics of Alzheimer´s disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

8

Country of publishing house

SE - SWEDEN

Number of pages

6

Pages from-to

691-696

UT code for WoS article

000350360300006

EID of the result in the Scopus database

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