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CD36 AA single nucleotide polymorphism (SNP) is associated with decreased lipid taste perception in Tunisian obese women: association with pro-inflammatory TNF-a GA and IL-6 GC genotypes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00083198" target="_blank" >RIV/00216224:14310/14:00083198 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/fcp.12064" target="_blank" >http://dx.doi.org/10.1111/fcp.12064</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/fcp.12064" target="_blank" >10.1111/fcp.12064</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    CD36 AA single nucleotide polymorphism (SNP) is associated with decreased lipid taste perception in Tunisian obese women: association with pro-inflammatory TNF-a GA and IL-6 GC genotypes

  • Original language description

    We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-a (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-a gene polymorphisms.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů