Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081602" target="_blank" >RIV/00216224:14310/15:00081602 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00455883 RIV/00216224:14310/15:00107138
Result on the web
<a href="http://pubs.acs.org/doi/10.1021/acs.est.5b02049" target="_blank" >http://pubs.acs.org/doi/10.1021/acs.est.5b02049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.est.5b02049" target="_blank" >10.1021/acs.est.5b02049</a>
Alternative languages
Result language
angličtina
Original language name
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
Original language description
Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappaB and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DJ - Pollution and water control
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GP13-27695P" target="_blank" >GP13-27695P: Immunomodulatory potencies of toxic cyanobacteria</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Technology
ISSN
0013-936X
e-ISSN
—
Volume of the periodical
49
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
12457-12464
UT code for WoS article
000363348700054
EID of the result in the Scopus database
—