Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00107138" target="_blank" >RIV/00216224:14310/15:00107138 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00455883 RIV/00216224:14310/15:00081602
Result on the web
<a href="http://pubs.acs.org/doi/abs/10.1021/acs.est.5b02049" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/acs.est.5b02049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.est.5b02049" target="_blank" >10.1021/acs.est.5b02049</a>

Result language
angličtina
Original language name
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
Original language description
Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)

Project
<a href="/en/project/GP13-27695P" target="_blank" >GP13-27695P: Immunomodulatory potencies of toxic cyanobacteria</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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