Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00083194" target="_blank" >RIV/00216224:14310/15:00083194 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/15:00063014
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0960076015001247" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960076015001247</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2015.04.019" target="_blank" >10.1016/j.jsbmb.2015.04.019</a>

Result language
angličtina
Original language name
Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling
Original language description
Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase II alpha. It is cytotoxicto breast, prostate, pituitary and myeloma cancer cell lines in vitro at mu M concentrations. In this study, however, a novel biological activity of nM dose of wedelolactone was demonstrated. Wedelolactone acts as agonist of estrogen receptors (ER) alphaand beta as demonstrated by transactivation of estrogen response element (ERE) in cells transiently expressing either ER alpha or ER beta and by molecular docking of this coumestan into ligand binding pocket of both ER alpha and ER beta. In breast cancer cells, wedelolactone stimulates growth of estrogen receptor-positive cells, expression of estrogen-responsive genes and activates rapid non-genomic estrogen signalling.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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