EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00116082" target="_blank" >RIV/00216224:14310/15:00116082 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/15:00472836

Result on the web

<a href="https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf" target="_blank" >https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Original language description

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T-3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Surprisingly, administration of Fluox in combination with supraphysiological amounts of T-3 caused a distinctive fall of non-physiologically high concentrations of serum total T-3, which were reached by giving the animals the same amounts of T-3 alone, to nearly normal levels. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. In conclusion, the elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20305 - Nuclear related engineering; (nuclear physics to be 1.3);

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH

ISBN

9788680300016

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

471-474

Publisher name

RAD ASSOC

Place of publication

Serbia

Event location

Budva, MONTENEGRO

Event date

Jun 8, 2015

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

000387979700098