EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00472836" target="_blank" >RIV/67985823:_____/15:00472836 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/15:00116082
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM
Original language description
In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. The elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH
ISBN
978-86-80300-01-6
ISSN
—
e-ISSN
—
Number of pages
4
Pages from-to
471-474
Publisher name
RAD ASSOC
Place of publication
Niš
Event location
Budva
Event date
Jun 8, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000387979700098