Sensitive determination of SEVNL and DAEFR pentapeptides as beta-secretase products by CE-C4D for its activity assay

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00088439" target="_blank" >RIV/00216224:14310/16:00088439 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sensitive determination of SEVNL and DAEFR pentapeptides as beta-secretase products by CE-C4D for its activity assay
Original language description
Alzheimer’s disease is the most common form of dementia; however, effective treatment is not yet available. Mechanism of the disease involves formation of neurotoxic oligomers of beta-amyloid peptides. These peptides are produced mainly by beta-secretase thus inhibition of the enzyme might be a way to treat the disease. In order to study enzyme’s inhibition – preferably with unlabeled substrates – high method’s sensitivity is demanded. Consequently, highly sensitive capillary electrophoresis based method with contactless conductivity detection was developed.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
13th International Interdisciplinary Meeting on Bioanalysis (CECE2016)
ISBN
9788090495944
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
191-194
Publisher name
Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic
Place of publication
Brno, Czech Republic
Event location
Brno, Czech Republic
Event date
Oct 17, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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