Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00093647" target="_blank" >RIV/00216224:14310/16:00093647 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/elan.201600321" target="_blank" >http://dx.doi.org/10.1002/elan.201600321</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elan.201600321" target="_blank" >10.1002/elan.201600321</a>

Result language

angličtina

Original language name

Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

Original language description

The paper is focused on the electrochemical investigation of DNA heptamers d(GCXXXGC) with different central triplets of nucleotides (XXX=GAA, AAA, CCC, GGG). On a hanging mercury electrode (HMDE), the reduction peaks of adenine (A) and cytosine (C) moieties are detectable, but those of guanine (G) moieties are covered by an intensive current of hydrogen evolution. Because cyclic voltammetry allows us to monitor only the oxidation processes of the G reduced species, the effect of hydrogen evolution reaction (HER) was studied by means of these anodic signals. For different vertex potentials (from -1.60V to -1.85V) and a different number of cycles (1-5), all heptamers in buffered solutions (pH5.8) were tested and double-peak G oxidation signals (GI and GII) evaluated. The different structures of the heptamers in solutions are confirmed by NMR spectra.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electroanalysis

ISSN

1040-0397

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

2841-2848

UT code for WoS article

000387891400028

EID of the result in the Scopus database

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