Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00097387" target="_blank" >RIV/00216224:14310/17:00097387 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/asia.201601515" target="_blank" >http://dx.doi.org/10.1002/asia.201601515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/asia.201601515" target="_blank" >10.1002/asia.201601515</a>
Alternative languages
Result language
angličtina
Original language name
Luminescent Ruthenium(II) Polypyridyl Complexes as Nonviral Carriers for DNA Delivery
Original language description
Two new luminescent ruthenium(II) polypyridyl complexes, [Ru(bpy)(2)(tpt-phen)]Cl-2 (1; bpy=2,2'-bipyridine, tpt-phen=triptycenyl-1,10-phenanthroline) and [Ru(phen)(2)(tpt-phen)]Cl-2 (2; phen=1,10-phenanthroline), have been developed as potential nonviral vectors for DNA delivery. Photophysical and electrochemical properties of the complexes have been investigated and corroborated with electronic structure calculations. DNA condensation by these complexes has been investigated by UV/Vis and emission spectroscopy, circular dichroism spectroscopy, atomic force microscopy, dynamic light scattering, confocal microscopy, and electrophoretic mobility studies. These complexes interact with DNA and efficiently condense DNA into globular nanoparticles that are taken up efficiently by HeLa cells. DNA cleavage inability and biocompatibility of complexes have been explored. Both complexes have good gene transfection abilities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/LM2015043" target="_blank" >LM2015043: Czech Infrastructure for Integrative Structural Biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - An Asian Journal
ISSN
1861-4728
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
254-264
UT code for WoS article
000393434200014
EID of the result in the Scopus database
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