Fast blood plasma separation device for point-of-care applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00111646" target="_blank" >RIV/00216224:14310/18:00111646 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/18:00486643
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0039914018301127" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039914018301127</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2018.02.004" target="_blank" >10.1016/j.talanta.2018.02.004</a>
Alternative languages
Result language
angličtina
Original language name
Fast blood plasma separation device for point-of-care applications
Original language description
In this work, a simple device for extremely fast separation of blood plasma from diluted whole blood was developed. The device accommodates an asymmetric polysulfone membrane/supporting membrane sandwich that allows collection of 10 mu L blood plasma into a narrow glass capillary in less than 10 s. The composition of diluent solution was optimized in order to achieve maximum recoveries for selected metabolites of alcohol intoxication. 5% solution of [tris(hydroxymethyl)methylamino] propanesulfonic acid provided recoveries of formate, oxalate and glycolate close to 100% and only moderate erythrocyte lysis. Both charged and uncharged compounds from the whole blood samples can be analyzed in the separated blood plasma by capillary electrophoresis with contactless conductometric detection and spectrophotometry, respectively. The developed device might find wide application in on-site testing and point-of-care analysis, when only microliter volumes of whole blood are available.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Talanta
ISSN
0039-9140
e-ISSN
1873-3573
Volume of the periodical
183
Issue of the periodical within the volume
JUN
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
55-60
UT code for WoS article
000430645800008
EID of the result in the Scopus database
2-s2.0-85042222134