In vitro and in vivo genotoxicity of oxygenated polycyclic aromatic hydrocarbons

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00113506" target="_blank" >RIV/00216224:14310/19:00113506 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/19:00502830

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0269749118336212" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0269749118336212</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2018.12.092" target="_blank" >10.1016/j.envpol.2018.12.092</a>

Result language

angličtina

Original language name

In vitro and in vivo genotoxicity of oxygenated polycyclic aromatic hydrocarbons

Original language description

Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) are a group of environmental pollutants found in complex mixtures together with PAHs. In contrast to the extensively studied PAHs, which have been established to have mutagenic and carcinogenic properties, much less is known about the effects of oxy-PAHs. The present work aimed to investigate the genotoxic potency of a set of environmentally relevant oxy-PAHs along with environmental soil samples in human bronchial epithelial cells (HBEC). We found that all oxy-PAHs tested induced DNA strand breaks in a dose-dependent manner and some of the oxy-PAHs further induced micronuclei formation. Our results showed weak effects in response to the oxy-PAH containing subfraction of the soil sample. The genotoxic potency was confirmed in both HBEC and HepG2 cells following exposure to oxy-PAHs by an increased level of phospho-Chk1, a biomarker used to estimate the carcinogenic potency of PAHs in vitro. We further exposed zebrafish embryos to single oxy-PAHs or a binary mixture with PAH benzo[a]pyrene (B[a]P) and found the mixture to induce comparable or greater effects on the induction of DNA strand breaks compared to the sum of that induced by B[a]P and oxy-PAHs alone. In conclusion, oxy-PAHs were found to elicit genotoxic effects at similar or higher levels to that of B[a]P which indicates that oxy-PAHs may contribute significantly to the total carcinogenic potency of environmental PAH mixtures. This emphasizes further investigations of these compounds as well as the need to include oxy-PAHs in environmental monitoring programs in order to improve health risk assessment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Pollution

ISSN

0269-7491

e-ISSN

—

Volume of the periodical

246

Issue of the periodical within the volume

MAR 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

678-687

UT code for WoS article

000458222100077

EID of the result in the Scopus database

2-s2.0-85059340934