Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F20%3A00114321" target="_blank" >RIV/00216224:14310/20:00114321 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/jssc.202000594" target="_blank" >https://doi.org/10.1002/jssc.202000594</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.202000594" target="_blank" >10.1002/jssc.202000594</a>
Alternative languages
Result language
angličtina
Original language name
Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin
Original language description
In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal analysis, and the obtained values of binding parameters were compared with the literature data. The affect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA19-08358S" target="_blank" >GA19-08358S: New approaches for the study of affinity interaction based on capillary electrophoresis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journa of Separation Science
ISSN
1615-9306
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
22
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
4225-4233
UT code for WoS article
000582531000001
EID of the result in the Scopus database
2-s2.0-85093661878