FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00119693" target="_blank" >RIV/00216224:14310/21:00119693 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075904
Result on the web
<a href="https://academic.oup.com/bib/article/22/4/bbaa337/6042664" target="_blank" >https://academic.oup.com/bib/article/22/4/bbaa337/6042664</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bib/bbaa337" target="_blank" >10.1093/bib/bbaa337</a>

Result language
angličtina
Original language name
FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction
Original language description
There is a great interest in increasing proteins' stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users' side. FireProt(ASR) aims to overcome this obstacle by constructing a fully automated workflow, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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