FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F20%3APU138651" target="_blank" >RIV/00216305:26230/20:PU138651 - isvavai.cz</a>

Result on the web

<a href="https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa337/6042664" target="_blank" >https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa337/6042664</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/bib/bbaa337" target="_blank" >10.1093/bib/bbaa337</a>

Result language

angličtina

Original language name

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Original language description

There is a great interest in increasing proteins stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users side. FireProtASR aims to overcome this obstacle by constructing a fully automated workf low, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProtASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BRIEFINGS IN BIOINFORMATICS

ISSN

1467-5463

e-ISSN

1477-4054

Volume of the periodical

0000

Issue of the periodical within the volume

0000

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000709466800097

EID of the result in the Scopus database

2-s2.0-85100417173