Pathogen sensing device based on 2D MoS2/graphene heterostructure.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00131702" target="_blank" >RIV/00216224:14310/23:00131702 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.snb.2023.134105" target="_blank" >https://doi.org/10.1016/j.snb.2023.134105</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2023.134105" target="_blank" >10.1016/j.snb.2023.134105</a>
Alternative languages
Result language
angličtina
Original language name
Pathogen sensing device based on 2D MoS2/graphene heterostructure.
Original language description
In this work we propose a new methodology for selective and sensitive pathogen detection based on a 2D layered heterostructured biosensing platform. As a proof of concept, we have chosen SARS-CoV-2 virus because the availability of new methods to detect this virus is still a great deal of interest. The prepared platform is based on the covalent immobilization of molybdenum disulphide functionalized with a diazonium salt (f-MoS2) onto graphene screen-printed electrodes (GPH SPE) by electrografting of the diazonium salt. This chemistry-based method generates an improved heterostructured biosensing platform for aptamer immobilization and aptasensor development. Electrochemical impedance spectroscopy (EIS) is used to obtain the signal response of the device, proving the ability of the sensor platform to detect the virus. SARS-CoV-2 spike RBD recombinant protein (SARS-CoV-2 S1 protein) has been detected and quantified with a low detection limit of 2.10 fg/mL. The selectivity of the developed biosensor has been confirmed after detecting the S1 protein even in presence of other interfering proteins. Moreover, the ability of the device to detect SARS-CoV-2 S1 protein has been also tested in nasopharyngeal swab samples.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors and Actuators B: Chemical
ISSN
0925-4005
e-ISSN
0925-4005
Volume of the periodical
392
Issue of the periodical within the volume
October
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1-10
UT code for WoS article
001058370400001
EID of the result in the Scopus database
2-s2.0-85162142016