What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00139717" target="_blank" >RIV/00216224:14310/23:00139717 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects
Original language description
The main aim of this work is the isolation, identification and examination of bioactive plant fractions with potential antiparasitic activity. These extracts are obtained from plants that are routinely eaten by orangutans. Our previous research suggests that the purpose of this consumption is self-medication. The main criteria for the plant selection are the behavioral data of the orangutans and the parasite infections thereof. The effect of these extracts on the progression of significant waterborne protozoal diseases (WBD), namely amoebiasis and giardiasis, is tested using both in vitro and in vivo methods. Moreover, the anthelmintic properties of the selected extract are investigated in vivo in a model nematode, Caenorhabditis elegans. Subsequently, activityguided fractionation is performed and active substances from these extracts are isolated and their chemical structure and biological activities are characterized.
Czech name
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Czech description
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Project
<a href="/en/project/GA23-06571S" target="_blank" >GA23-06571S: What orang-utans can teach us: plants used for self-medication as a potential source of bioactive substances with amoebicidal and antigiardial effects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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