Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00140788" target="_blank" >RIV/00216224:14310/25:00140788 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202424754" target="_blank" >10.1002/anie.202424754</a>
Alternative languages
Result language
angličtina
Original language name
Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
Original language description
Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
<a href="/en/project/GA23-05271S" target="_blank" >GA23-05271S: Chemical modification of bambusurils for adjusting their binding affinity and selectivity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie International Edition
ISSN
1433-7851
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1-7
UT code for WoS article
001432066300041
EID of the result in the Scopus database
2-s2.0-85215506515