Synthesis of new Ag(i) and Cd(ii) hydrozanomide-based complexes with antibacterial and anticancer properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00141475" target="_blank" >RIV/00216224:14310/25:00141475 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra02001h" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra02001h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d5ra02001h" target="_blank" >10.1039/d5ra02001h</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of new Ag(i) and Cd(ii) hydrozanomide-based complexes with antibacterial and anticancer properties
Original language description
A series of new Ag(i) and Cd(ii) hydrozanomide-based complexes have been prepared and studied. The synthesized compounds have undergone extensive spectroscopic and structural characterization, including F-AAS, FTIR, single crystal XRD and TGA analyses. Crystal structures of two representative complexes, 4 and 6, have revealed that the silver atom in complex 4 assumes a four-coordinate geometry with two ligands. Additionally, the stability of these complexes in DMSO has been determined using UV-vis spectroscopy. The biological activity of these metal complexes has been assessed, focusing on their antibacterial and anticancer properties against LN-229 and U87 cell lines. Among the tested compounds, silver-based complexes demonstrated significant antibacterial activity against a wide range of microorganisms. Moreover, cytotoxicity studies have shown that the metal complexes exhibit higher anticancer activity compared to their parent ligands. Notably, the Ag(i) complexes of L3, L4, and L5 have emerged as the most promising candidates for their selective toxicity against cancer cells, without harmful effects on normal human fibroblast cells. These findings highlight the potential of Ag(i) complexes as promising anticancer agents with selective toxicity and potent antibacterial properties.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RSC Advances
ISSN
2046-2069
e-ISSN
2046-2069
Volume of the periodical
15
Issue of the periodical within the volume
25
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
19598-19609
UT code for WoS article
001504785000001
EID of the result in the Scopus database
2-s2.0-105008023533